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Galini Moghadam T, Mahmoodi Nesheli H. Isolated Ocular Relapse of Acute Lymphoblastic Leukemia in Down Syndrome: A Case Report and Literature Review. CJP 2024; 10
URL: http://caspianjp.ir/article-1-204-fa.html
URL: http://caspianjp.ir/article-1-204-fa.html
Isolated Ocular Relapse of Acute Lymphoblastic Leukemia in Down Syndrome: A Case Report and Literature Review. مجله کاسپین کودکان. 1402; 10 ()
چکیده: (131 مشاهده)
Background and Objective: Relapse of acute lymphoblastic leukemia (ALL) usually occurs in the bone marrow, testes and brain, but the occurrence of relapse in the orbits seems to be rare. In this case, we present a relapse of ALL that occurred in the eyes.
Case Report: A 9-year-old girl with Down syndrome, a known case of ALL, was in remission after complete chemotherapy ( Berlin-Frankfurt-Munich (BFM) protocol) and presented to Amirkola Children' Hospital with conjunctivitis and blurred vision. She had been in remission for one year (since 1991-1992). Paracentesis of the anterior chamber was performed to obtain a sample of the aqueous humor for cytology. The smear revealed involvement of the eye with leukemic cells. Hematologic examinations were performed. The bone marrow and central nervous system (CNS) were normal. While we continued chemotherapy for four months, the patient presented with headache and bone pain. A re-examination revealed that she had a relapse in the bone marrow and CNS. She died from leukemia, despite appropriate therapy.
Conclusion: Ocular paracentesis should be performed without delay when blurred vision develops in ALL, regardless of systemic signs and symptoms.
Case Report: A 9-year-old girl with Down syndrome, a known case of ALL, was in remission after complete chemotherapy ( Berlin-Frankfurt-Munich (BFM) protocol) and presented to Amirkola Children' Hospital with conjunctivitis and blurred vision. She had been in remission for one year (since 1991-1992). Paracentesis of the anterior chamber was performed to obtain a sample of the aqueous humor for cytology. The smear revealed involvement of the eye with leukemic cells. Hematologic examinations were performed. The bone marrow and central nervous system (CNS) were normal. While we continued chemotherapy for four months, the patient presented with headache and bone pain. A re-examination revealed that she had a relapse in the bone marrow and CNS. She died from leukemia, despite appropriate therapy.
Conclusion: Ocular paracentesis should be performed without delay when blurred vision develops in ALL, regardless of systemic signs and symptoms.
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