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Devimeenakshi K, SathishKumar K. Factors Influencing Outcome of Neonates with Perinatal Asphyxia in a Tertiary Care Hospital. CJP 2024; 10
URL: http://caspianjp.ir/article-1-230-en.html
URL: http://caspianjp.ir/article-1-230-en.html
Government Kilpauk Medical College, Chennai, Tamil Nadu, India , drdevi_1804@yahoo.in
Abstract: (141 Views)
Background and Objective: Perinatal asphyxia is one of the major contributors to neonatal mortality in developing countries. Identification of factors influencing the early outcome in perinatal asphyxia will help to plan necessary interventions. The aim of this study was to evaluate the factors influencing the early outcome of asphyxiated neonates.
Methods: This retrospective cohort study was conducted on asphyxiated neonates admitted to the neonatal intensive care unit (NICU) of a tertiary Medical college hospital in Chennai, Tamilnadu, India, from January to December 2016. The relationship between the risk factors and early outcome of asphyxia was analyzed using a statistical chi-square test. A multivariate analysis was performed to determine the factors influencing the outcome. A value of p<0.05 was considered significant.
Findings: Of 346 asphyxiated neonates, 42 (12.1%) died. Multivariate analysis revealed that factors like parity (OR:0.018, p-value=0.01), birth weight (OR:3.217, P-value=0.04), meconium stained liquor (MSL) (OR:3.217, p-value=0.03), APGAR score at five minutes (OR:0.533, p-value=0.04), shock (OR:4.123, p-value=0.01), and abnormal cranial ultrasound (OR:2.390, p-value=0.03), and mechanical ventilation (OR:13.496, p-value=0.03), were significantly associated with outcome.
Conclusion: The current study revealed that maternal factors such as parity, intrapartum factors like MSL, low five-minute Apgar score, neonatal factors like birth weight, shock, abnormal cranial ultrasound, and mechanical ventilation had a significant impact on the mortality of neonates with perinatal asphyxia. As many of these factors are modifiable, better intrapartum monitoring and timely initiation of corrective measures may help to improve the early outcome of asphyxiated neonates.
Methods: This retrospective cohort study was conducted on asphyxiated neonates admitted to the neonatal intensive care unit (NICU) of a tertiary Medical college hospital in Chennai, Tamilnadu, India, from January to December 2016. The relationship between the risk factors and early outcome of asphyxia was analyzed using a statistical chi-square test. A multivariate analysis was performed to determine the factors influencing the outcome. A value of p<0.05 was considered significant.
Findings: Of 346 asphyxiated neonates, 42 (12.1%) died. Multivariate analysis revealed that factors like parity (OR:0.018, p-value=0.01), birth weight (OR:3.217, P-value=0.04), meconium stained liquor (MSL) (OR:3.217, p-value=0.03), APGAR score at five minutes (OR:0.533, p-value=0.04), shock (OR:4.123, p-value=0.01), and abnormal cranial ultrasound (OR:2.390, p-value=0.03), and mechanical ventilation (OR:13.496, p-value=0.03), were significantly associated with outcome.
Conclusion: The current study revealed that maternal factors such as parity, intrapartum factors like MSL, low five-minute Apgar score, neonatal factors like birth weight, shock, abnormal cranial ultrasound, and mechanical ventilation had a significant impact on the mortality of neonates with perinatal asphyxia. As many of these factors are modifiable, better intrapartum monitoring and timely initiation of corrective measures may help to improve the early outcome of asphyxiated neonates.
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